Chemotherapy aims to kill cancer—not revive it. But a new Cancer Cell study by He et al shows common drugs like doxorubicin and cisplatin can reactivate dormant tumor cells, leading to deadly metastatic relapses, especially in the lungs. These “sleeping” disseminated tumor cells (DTCs) can stay hidden for years before chemo wakes them up. This is the first study to directly prove chemo can trigger cancer’s return.
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